The hospital named as Road Hospital is only a few years old. It was created on the basis of a railway hospital with a history of more than 100 years.

The first story of a railway hospital at the Minsk station dated on 1889. It was created by the Moscow-Brest Railway Society, was maintained at its expense, was intended for medical care of its employees, had a capacity of 6 places, and was located in the building of a technical railway school. The doctor S. Ioffe was in charge of the hospital.

The Minsk railway center included two lines: Moscow-Brest line and Libavo-Romenskaya line. Medical care for railway workers, in addition to the hospital, was provided by 4 outpatient clinics, which at that time were called emergency rooms. They employed 4 doctors, 4 paramedics and 2 dentists. Medical personnel were trained to assist in accidents and crashes. Its equipment included a set of medicines and dressings, obstetric bags, stretchers.

In 1914, the construction of a railway hospital was completed. But  the hospital building was given over to a military hospital for wounded soldiers because First World War.

Real opening of the railway hospital took place in 1922. Its capacity is 52 beds (20 therapeutic, 20 surgical, 12 infectious). The first chief doctor of the hospital - Professor Sergei Lebedkin - Head of the Department of Anatomy of the Medical Faculty of the Belarusian State University.

In subsequent years, the hospital expanded. In the early 1930s, the number of beds increased to 70, in 1936 another 40 were put into operation, and by the beginning of the Great Patriotic War, it had 155 beds. There were departments: therapeutic, surgical, obstetric-gynecological, tuberculosis.

During the Second World war, the hospital suffered significant damage. But already a month after the liberation of Minsk, 100 beds functioned in the restored building, and in 1947 - 176 places.

In 1953, on the basis of the Minsk Railway Hospital, a methodological, consultative and medical center was organized for the entire Belarusian Railway and a road hospital for 250 places. By 1967, the hospital had been expanded to 275 places. In 1970, a new hospital was put into operation in another place in Minsk. It is merged with its predecessor under a single management, with a total bed capacity of places.

Outpatient care for railway workers and members of their families was provided in a polyclinic located in the first building of the hospital at Minsk-Commodity station. In 1988 on the street Voronyansky put into operation a new clinic for adults and children for 840 visits per shift.

Over the years, the hospital was headed by doctors: in the pre-war period, Sergei Ivanovich Lebedkin (1922 - 1926), Dolmatsky (since 1926), Pavel Pavlovich Dolgolikov (since 1939), and in the post-war period - Grechikova Zinaida Vasilievna, German Iosif Petrovich, Konopelko Vasily Vasilievich, Syapich Pavel Ignatievich, Korvigov Gennady Konstantinovich, Vechersky Grigory Arsentievich (1968 - 1970), Okunev Ivan Martynovich (1970 - 1978), Zyuzenkov Viktor Vasilievich (1978 - 2000 d.), Drozdov Alexander Ivanovich (2001 - 2002), Krylovich Valery Nikolaevich (2002 - 2003). Lunevsky Vitaly Adamovich (2003-2010), Kazachenok Zhanna Viktorovna (2010-2020), Vrublevsky Valery Anatolyevich (2021-2022), Tabankov Andrey (2023-2024).